Lrp1b^tm1Her
Targeted Allele Detail

Summary

• Symbol: Lrp1b^tm1Her
• Name: low density lipoprotein-related protein 1B; targeted mutation 1, Joachim Herz
• MGI ID: MGI:3045402
• Synonyms: Lrp1b^-
• Gene: Lrp1b Location: Chr2:40485258-42543636 bp, - strand Genetic Position: Chr2, 24.51 cM, cytoband B
• Alliance: Lrp1b^tm1Her page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:90197
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S/SvEv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 88, which encodes the membrane-spanning segment, was replaced with a neo. Allele-specific PCR was used to detect the gene disruption and Western blot confirmed absence of the protein in mutant brains. (J:90197)

Tumor Data

List all tumor models in MMHCdb carrying Lrp1b^tm1Her

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lrp1b Mutation: 304 strains or lines available

References

• Original: J:90197 Marschang P, et al., Normal development and fertility of knockout mice lacking the tumor suppressor gene LRP1b suggest functional compensation by LRP1. Mol Cell Biol. 2004 May;24(9):3782-93
• All: 1 reference(s)