Btla^tm1Kay
Targeted Allele Detail

Summary

• Symbol: Btla^tm1Kay
• Name: B and T lymphocyte associated; targeted mutation 1, Jonathan Kaye
• MGI ID: MGI:3045408
• Synonyms: BTLA^-
• Gene: Btla Location: Chr16:45043121-45073258 bp, + strand Genetic Position: Chr16, 29.52 cM
• Alliance: Btla^tm1Kay page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:89864
• Parent Cell Line: CMTI-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: Exon 2, which encodes the Ig-like domain, was disrupted by the insertion of a neo in reverse transcriptional orientation via homologous recombination. Southern blots confirmed gene targeting and RT-PCR indicated failure of mutant spleen cells to express full-length mRNA. (J:89864)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Btla Mutation: 30 strains or lines available

References

• Original: J:89864 Han P, et al., An inhibitory Ig superfamily protein expressed by lymphocytes and APCs is also an early marker of thymocyte positive selection. J Immunol. 2004 May 15;172(10):5931-9
• All: 6 reference(s)