Cnr1^tm1.2Ltz
Targeted Allele Detail

Summary

• Symbol: Cnr1^tm1.2Ltz
• Name: cannabinoid receptor 1; targeted mutation 1.2, Beat Lutz
• MGI ID: MGI:3045419
• Synonyms: CB1^f
• Gene: Cnr1 Location: Chr4:33924593-33948831 bp, + strand Genetic Position: Chr4, 16.28 cM
• Alliance: Cnr1^tm1.2Ltz page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:89842
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: This allele was generated by breeding mice homozygous for Cnr1^tm1Ltz with transgenic mice ubiquitously expressing flip recombinase, thereby leaving the floxed coding region. Southern blot and PCR analysis confirmed recombination. mRNA was present in pyramidal neurons. (J:89842)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Cnr1 Mutation: 42 strains or lines available

References

• Original: J:89842 Marsicano G, et al., CB1 cannabinoid receptors and on-demand defense against excitotoxicity. Science. 2003 Oct 3;302(5642):84-8
• All: 104 reference(s)