Ctnnbip1^tm1Taki
Targeted Allele Detail

Summary

• Symbol: Ctnnbip1^tm1Taki
• Name: catenin beta interacting protein 1; targeted mutation 1, Tetsu Akiyama
• MGI ID: MGI:3045424
• Synonyms: ICAT-
• Gene: Ctnnbip1 Location: Chr4:149602698-149650894 bp, + strand Genetic Position: Chr4, 79.66 cM
• Alliance: Ctnnbip1^tm1Taki page

Developmental defect images

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:90666
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A neo cassette was inserted 11 amino acids downstream of the first initiation site via homologous recombination. Immunoblotting analysis confirmed the absence of protein expression in homozygous mice. (J:90666)

Expression

In Mice Carrying this Mutation:	4 assay results
In Structures Affected by this Mutation:	9 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ctnnbip1 Mutation: 12 strains or lines available

References

• Original: J:90666 Satoh K, et al., Anteriorization of neural fate by inhibitor of beta-catenin and T cell factor (ICAT), a negative regulator of Wnt signaling. Proc Natl Acad Sci U S A. 2004 May 25;101(21):8017-21
• All: 3 reference(s)