Sstr2^tm1Pce
Targeted Allele Detail

Summary

• Symbol: Sstr2^tm1Pce
• Name: somatostatin receptor 2; targeted mutation 1, Piers C Emson
• MGI ID: MGI:3045430
• Synonyms: sst2-KO, Sstr2^lacZ
• Gene: Sstr2 Location: Chr11:113510168-113516854 bp, + strand Genetic Position: Chr11, 79.05 cM
• Alliance: Sstr2^tm1Pce page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:126001
• Parent Cell Line: HM-1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd-Hprt1^b-m3

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The first 654 bp of the single exon gene was replaced with a lacZ reporter and a neomycin resistance gene, with the initiation codon of lacZ inserted in frame with original the transcription start site. Southern blot confirmed recombination and reverse transcription PCR demonstrated absence of normal mRNA and presence of lacZ mRNA in mutants. (J:89708)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sstr2 Mutation: 33 strains or lines available

References

• Original: J:126001 Allen JP, et al., Identification of cells expressing somatostatin receptor 2 in the gastrointestinal tract of Sstr2 knockout/lacZ knockin mice. J Comp Neurol. 2002 Dec 16;454(3):329-40
• All: 10 reference(s)