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Teftm1Schb
Targeted Allele Detail
Summary
Symbol: Teftm1Schb
Name: thyrotroph embryonic factor; targeted mutation 1, Ueli Schibler
MGI ID: MGI:3045494
Synonyms: PAR bZIP-, Tef-
Gene: Tef  Location: Chr15:81686874-81711064 bp, + strand  Genetic Position: Chr15, 38.25 cM
Alliance: Teftm1Schb page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:90854
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA lacZ and PGK-neo replaced exon 2, which encodes the transactivation domain. Western blot indicated no presence of protein in livers of mutants. (J:90854)
Phenotypes
Key:
hm homozygous ht heterozygous tg involves transgenes phenotype observed
cn conditional genotype  cx complex: > 1 genome feature ot other: hemizygous, indeterminate,... N normal phenotype
Genotype/
Background:
Allelic Composition
Genetic Background
Cell Line(s)
Allelic CompositionGenetic BackgroundCell Line(s)
involves: 129S2/SvPas
 
involves: 129P2/OlaHsd * 129S2/SvPas
 
involves: 129P2/OlaHsd * 129S2/SvPas
 
involves: 129P2/OlaHsd * 129S2/SvPas
 
involves: 129S2/SvPas
 
Phenotypes:
Affected Systems
show or hide all annotated terms
         
behavior/neurological
impaired behavioral response to xenobiotic
seizures
audiogenic seizures
tonic-clonic seizures
absence seizures
cardiovascular system
cardiac hypertrophy
hypotension
growth/size/body
cardiac hypertrophy
enlarged liver
homeostasis/metabolism
decreased circulating aldosterone level
increased circulating alanine transaminase level
decreased dopamine level
decreased serotonin level
increased physiological sensitivity to xenobiotic
liver/biliary system
enlarged liver
mortality/aging
premature death
nervous system
seizures
audiogenic seizures
tonic-clonic seizures
absence seizures
abnormal brain morphology
abnormal brain wave pattern
View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 1 RNA-Seq or microarray experiment(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Tef Mutation:  13 strains or lines available
References
Original:  J:90854 Gachon F, et al., The loss of circadian PAR bZip transcription factors results in epilepsy. Genes Dev. 2004 Jun 15;18(12):1397-412
All:  10 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory