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Gfra3tm1Wss
Targeted Allele Detail
Summary
Symbol: Gfra3tm1Wss
Name: glial cell line derived neurotrophic factor family receptor alpha 3; targeted mutation 1, W Scott Simonet
MGI ID: MGI:3045508
Gene: Gfra3  Location: Chr18:34822951-34853440 bp, - strand  Genetic Position: Chr18, 18.69 cM
Alliance: Gfra3tm1Wss page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:90843
Parent Cell Line:  RW-4 (ES Cell)
Strain of Origin:  129X1/SvJ
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsAn 11 kb segment of the gene including exons 1 and 2 and encoding amino acids 2 to 123 was replaced with a lacZ/neo cassette. The cassette was fused in frame. Recombination was confirmed by Southern blot and PCR and RT-PCR indicated absence of gene expression in mutant mice. (J:90843)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gfra3 Mutation:  33 strains or lines available
References
Original:  J:90843 Bolon B, et al., The candidate neuroprotective agent artemin induces autonomic neural dysplasia without preventing peripheral nerve dysfunction. Toxicol Pathol. 2004 May-Jun;32(3):275-94
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/19/2024
MGI 6.24
The Jackson Laboratory