Tg(TcraH-Y,TcrbH-Y)1Pas
Transgene Detail

Summary

• Symbol: Tg(TcraH-Y,TcrbH-Y)1Pas
• Name: transgene insertion 1, Institut Pasteur
• MGI ID: MGI:3045612
• Synonyms: Marilyn, TCR-alpha (V1.1-J35)/TCRbeta (V6-J2.3), Tcrbav1.1, Tcrbv6
• Transgene: Tg(TcraH-Y,TcrbH-Y)1Pas Location: unknown
• Alliance: Tg(TcraH-Y,TcrbH-Y)1Pas page

Transgene origin

• Strain of Origin: C57BL/6

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(TcraH-Y,TcrbH-Y)1Pas expresses 2 genes
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Tcra (MGI:98553)
  mouse	Tcrb (MGI:98578)

• Mutation details: The two coinjected transgenes comprise functionally rearranged genomic T-cell receptor alpha and T-cell receptor beta genes that recognize the male specific H-Y antigen in the context of the major histocompatibility (H2) class II I-A^b29 protein. The joined V-J segments of the T-cell receptor alpha transgene and V-D-J segments of the T-cell receptor beta transgene were isolated from the CD4 T-cell clone "Marilyn" and inserted into expression, or shuttle, vectors that contain genomic sequences including the constant-region exons of Tcra and Tcrb and their associated promoters and enhancers. (J:90556)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 3 strains available Cell Lines: 0 lines available

References

• Original: J:90556 Lantz O, et al., Gamma chain required for naive CD4+ T cell survival but not for antigen proliferation. Nat Immunol. 2000 Aug;1(1):54-8
• All: 62 reference(s)