Chuk^tm2Mka
Targeted Allele Detail

Summary

• Symbol: Chuk^tm2Mka
• Name: conserved helix-loop-helix ubiquitous kinase; targeted mutation 2, Michael Karin
• MGI ID: MGI:3045616
• Synonyms: Ikka^AA, IKKalpha^AA
• Gene: Chuk Location: Chr19:44061774-44095919 bp, - strand Genetic Position: Chr19, 36.71 cM
• Alliance: Chuk^tm2Mka page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:90978
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted
• Mutation: Insertion
• Mutation details: Serines 176 and 180, located in exon 6, were replaced with alanines following homologous recombination. A floxed neo was excised from between exons 7 and 8 via transient Cre-mediated recombination. RT-PCR of liver tissue demonstrated expression of the mutant allele. (J:90978)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Chuk Mutation: 51 strains or lines available

References

• Original: J:90978 Cao Y, et al., IKKalpha provides an essential link between RANK signaling and cyclin D1 expression during mammary gland development. Cell. 2001 Dec 14;107(6):763-75
• All: 21 reference(s)