Ptges^tm1Lpa
Targeted Allele Detail

Summary

• Symbol: Ptges^tm1Lpa
• Name: prostaglandin E synthase; targeted mutation 1, Laurent P Audoly
• MGI ID: MGI:3045658
• Synonyms: mPGES-1-, MPGES1-
• Gene: Ptges Location: Chr2:30779483-30793309 bp, - strand Genetic Position: Chr2, 21.75 cM
• Alliance: Ptges^tm1Lpa page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:90980
• Parent Cell Line: DBA-252 (ES Cell)
• Strain of Origin: DBA/1LacJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neo was inserted to replace part of exon 1 and all of exon 2, corresponding to base pairs 35-256 of the cDNA sequence. Western blot indicated absence of protein in mutant macrophages. (J:90980)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ptges Mutation: 48 strains or lines available

References

• Original: J:90980 Trebino CE, et al., Impaired inflammatory and pain responses in mice lacking an inducible prostaglandin E synthase. Proc Natl Acad Sci U S A. 2003 Jul 22;100(15):9044-9
• All: 53 reference(s)