Tgfbr2^tm1Roes
Targeted Allele Detail

Summary

• Symbol: Tgfbr2^tm1Roes
• Name: transforming growth factor, beta receptor II; targeted mutation 1, Jurgen Roes
• MGI ID: MGI:3045693
• Synonyms: TbetaRII^fl, TbRII^fl, TGFbetaRII^lox
• Gene: Tgfbr2 Location: Chr9:115916763-116004431 bp, - strand Genetic Position: Chr9, 68.39 cM
• Alliance: Tgfbr2^tm1Roes page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:90558
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A floxed neomycin resistance gene was introduced in intron 2 and a single loxP site about 1 kb downstream from exon 3 by homologous recombination; transient expression of Cre recombinase in ES cells excised the neo gene, leaving exon 3 flanked by single loxP sites. (J:90558)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Tgfbr2 Mutation: 40 strains or lines available

References

• Original: J:90558 Cazac BB, et al., TGF-beta receptor controls B cell responsiveness and induction of IgA in vivo. Immunity. 2000 Oct;13(4):443-51
• All: 13 reference(s)