Tg(Pax6-cre,GFP)1Pgr
Transgene Detail

Summary

• Symbol: Tg(Pax6-cre,GFP)1Pgr
• Name: transgene insertion 1, Peter Gruss
• MGI ID: MGI:3045749
• Synonyms: Le-Cre, Le-Cre-GFP, Lens-Cre, P0-3.9-GFPCre, Pax6Cre, Pax6(LP)-Cre, Tg(Pax6-cre,GFP)1Pgr
• Transgene: Tg(Pax6-cre,GFP)1Pgr Location: unknown
• Alliance: Tg(Pax6-cre,GFP)1Pgr page

Transgene origin

• Strain of Origin: FVB

Transgene description

• Transgene Type: Transgenic (Recombinase)
• Mutation: Insertion
• Tg(Pax6-cre,GFP)1Pgr expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Pax6 (MGI:97490)

• Mutation details: This transgene consists of a 6.5 kb genomic fragment upstream of the murine Pax6 gene, an nlsCre, an IRES, EGFP, and a polyadenylation signal. The Pax6 promoter fragment drives expression of Cre and GFP in the surface ectoderm, developing lens, cornea, and pancreas in transgenic mice. (J:65765)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Pax6 (mouse) Summary of all recombinase alleles driven by Pax6. Comparative matrix view of recombinase activities Alliance mouse Pax6 gene page

Disease models

Expression

In Mice Carrying this Mutation:

285 assay results 25 RNA-Seq or microarray experiment(s)

Tumor Data

List all tumor models in MMHCdb carrying Tg(Pax6-cre,GFP)1Pgr

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available

References

• Original: J:65765 Ashery-Padan R, et al., Pax6 activity in the lens primordium is required for lens formation and for correct placement of a single retina in the eye. Genes Dev. 2000 Nov 1;14(21):2701-11
• All: 146 reference(s)