Tlr12^tm1Gho
Targeted Allele Detail

Summary

• Symbol: Tlr12^tm1Gho
• Name: toll-like receptor 12; targeted mutation 1, Sankar Ghosh
• MGI ID: MGI:3045751
• Synonyms: TLR11^-
• Gene: Tlr12 Location: Chr4:128509239-128512412 bp, - strand Genetic Position: Chr4, 62.08 cM
• Alliance: Tlr12^tm1Gho page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:89754
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Coding sequence was replaced with a neomycin selection cassette through homologous recombination. RT-PCR analysis on kidney mRNA derived from homozygous mice demonstrated that no detectable transcript was expressed from this allele. (J:89754)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tlr12 Mutation: 32 strains or lines available

Notes

Confusion exists regarding the identity of Tlr11 and Tlr12. All of the references listed below identify this allele as an allele of Tlr11. However, all of the associated sequence information indicates that this is, in fact, an allele of Tlr12. J:89754 J:113110 J:114880 J:125088 J:142066 J:150494

References

• Original: J:89754 Zhang D, et al., A toll-like receptor that prevents infection by uropathogenic bacteria. Science. 2004 Mar 5;303(5663):1522-6
• All: 24 reference(s)