Rplag^FVB/NJ
QTL Variant Detail

Summary

• QTL variant: Rplag^FVB/NJ
• Name: reduced platelet aggregation; FVB/NJ
• MGI ID: MGI:3045767
• QTL: Rplag Location: Chr13:112502130-112502244 bp Genetic Position: Chr13, cM position of peak correlated region/allele: 63.73 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: FVB/NJ

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers decreased platelet Itga2 expression compared to C57BL/6J. (J:90287)

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:90287

Inbred strain FVB/NJ expresses 50% less integrin alpha 2 on blood platelets compared to inbred strains C57BL/6J, 129X1/SvJ, C3H/HeJ, and BALB/cJ. Platelets from FVB/NJ mice exhibit reduced collagen-induced aggregation and longer lag time to collagen compared to other strains. Twenty (FVB/NJ x C57BL/6J)F2 animals were typed for D13Mit260, a marker at 83 cM on mouse Chromosome 13 near the Itga2 gene. D13Mit260 showed linkage to reduced Itga2 expression with LOD=6.7 and this locus is named Rplag (reduced platelet aggregation). Authors theorize polymorphisms in the Itga2 regulatory region may be responsible for the 2-fold reduction in integrin alpha 2 expression and reduced platelet aggregation phenotype observed in FVB/NJ mice.

References

• Original: J:90287 Li TT, et al., Genetic variation responsible for mouse strain differences in integrin alpha 2 expression is associated with altered platelet responses to collagen. Blood. 2004 May 1;103(9):3396-402
• All: 1 reference(s)