Rfx3^tm1Wrth
Targeted Allele Detail

Summary

• Symbol: Rfx3^tm1Wrth
• Name: regulatory factor X, 3 (influences HLA class II expression); targeted mutation 1, W Reith
• MGI ID: MGI:3045791
• Synonyms: Rfx3^flox,neoR
• Gene: Rfx3 Location: Chr19:27739121-27988566 bp, - strand Genetic Position: Chr19, 22.36 cM, cytoband C1
• Alliance: Rfx3^tm1Wrth page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:89880
• Parent Cell Line: ENS (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Loxp sites were inserted to flank exon 3, which encodes the DNA binding domain. An FRT flanked neo was inserted in inton 2. Recombination was confirmed by Southern blot and PCR. (J:89880)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rfx3 Mutation: 68 strains or lines available

References

• Original: J:89880 Bonnafe E, et al., The transcription factor RFX3 directs nodal cilium development and left-right asymmetry specification. Mol Cell Biol. 2004 May;24(10):4417-27
• All: 1 reference(s)