Rfx3^tm2Wrth
Targeted Allele Detail

Summary

• Symbol: Rfx3^tm2Wrth
• Name: regulatory factor X, 3 (influences HLA class II expression); targeted mutation 2, W Reith
• MGI ID: MGI:3045793
• Synonyms: Rfx3^flox
• Gene: Rfx3 Location: Chr19:27739121-27988566 bp, - strand Genetic Position: Chr19, 22.36 cM, cytoband C1
• Alliance: Rfx3^tm2Wrth page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:89880
• Parent Cell Line: ENS (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Loxp sites were inserted to flank exon 3, which encodes the DNA binding domain. An FRT-flanked neo was removed via transient FLP-mediated excision. Recombination was confirmed by Southern blot and PCR. (J:89880)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rfx3 Mutation: 68 strains or lines available

References

• Original: J:89880 Bonnafe E, et al., The transcription factor RFX3 directs nodal cilium development and left-right asymmetry specification. Mol Cell Biol. 2004 May;24(10):4417-27
• All: 4 reference(s)