Rr152^tm2Cog
Targeted Allele Detail

Summary

• Symbol: Rr152^tm2Cog
• Name: regulatory region 152; targeted mutation 2, Michel Cogne
• MGI ID: MGI:3045811
• Synonyms: deltaImu-Cmu intron, Igh^tm2Cog
• Gene: Rr152 Location: Chr12:113191890-113217660 bp Genetic Position: Chr12, Syntenic
• Alliance: Rr152^tm2Cog page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:90548
• Parent Cell Line: CK35 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Modified regulatory region, Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: This allele has a deletion of approximately 4.6 kb in the Imu-Cmu intron. Cre-mediated recombination removed a floxed neo inserted in the intron, leaving a loxp sequence. Homozygous mutants displayed a 5- to 20-fold decrease in surface expression of IgG1, IgG3 and IgA, and a 2- to 5- fold decrease in IgG2b and IgG2a as compared to wild-type. No alteration was found in IgM expression. (J:90548)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Rr152 Mutation: 0 strains or lines available

References

• Original: J:90548 Khamlichi AA, et al., Immunoglobulin class-switch recombination in mice devoid of any S mu tandem repeat. Blood. 2004 May 15;103(10):3828-36
• All: 2 reference(s)