Myb^Plt4
Chemically induced Allele Detail

Summary

• Symbol: Myb^Plt4
• Name: myeloblastosis oncogene; Plt4
• MGI ID: MGI:3045843
• Synonyms: c-Myb^Plt4
• Gene: Myb Location: Chr10:21000834-21036883 bp, - strand Genetic Position: Chr10, 9.75 cM
• Alliance: Myb^Plt4 page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: As a result of an A to T transversion, this allele has an aspartic acid to valine mutation at residue 384 in the leucine-zipper domain. Northern blot indicates mRNA is expressed at normal levels in hematopoitic tissues but a transactivation assay revealed a significant reduction in protein activity as compared to wild-type. (J:89601)
• Inheritance: Semidominant

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Myb Mutation: 53 strains or lines available

References

• Original: J:89601 Carpinelli MR, et al., Suppressor screen in Mpl-/- mice: c-Myb mutation causes supraphysiological production of platelets in the absence of thrombopoietin signaling. Proc Natl Acad Sci U S A. 2004 Apr 27;101(17):6553-8
• All: 9 reference(s)