Nkx3-1^tm1.1Saa
Targeted Allele Detail

Summary

• Symbol: Nkx3-1^tm1.1Saa
• Name: NK3 homeobox 1; targeted mutation 1.1, Sarki A Abdulkadir
• MGI ID: MGI:3045877
• Synonyms: Nkx3.1^-
• Gene: Nkx3-1 Location: Chr14:69428141-69432107 bp, + strand Genetic Position: Chr14, 36.02 cM
• Alliance: Nkx3-1^tm1.1Saa page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:74350
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: As a result of crossing Nkx3-1^tm1Saa with transgenic mice expressing cre in the germ line, the floxed exon 2 and neo cassette were excised, leaving exon 1 and a single loxP site. RT-PCR analysis and immunohistochemical analyses confirmed loss of mRNA and protein expression in the posterior prostates of mutant mice. (J:74350)

Tumor Data

List all tumor models in MMHCdb carrying Nkx3-1^tm1.1Saa

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nkx3-1 Mutation: 38 strains or lines available

References

• Original: J:74350 Abdulkadir SA, et al., Conditional loss of nkx3.1 in adult mice induces prostatic intraepithelial neoplasia. Mol Cell Biol. 2002 Mar;22(5):1495-503
• All: 7 reference(s)