Card11^tm1Pngr
Targeted Allele Detail

Summary

• Symbol: Card11^tm1Pngr
• Name: caspase recruitment domain family, member 11; targeted mutation 1, Josef M Penninger
• MGI ID: MGI:3045950
• Synonyms: card11^-, carma1 ko
• Gene: Card11 Location: Chr5:140858745-140986337 bp, - strand Genetic Position: Chr5, 79.42 cM
• Alliance: Card11^tm1Pngr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:84036
• Parent Cell Line: E14K (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 4 and part of exon 5, including the start codon and the code for the CARD region, were replaced with a neo cassette. Western blot of splenocytes indicated absence of protein in mutant animals. (J:84036)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Card11 Mutation: 59 strains or lines available

References

• Original: J:84036 Hara H, et al., The MAGUK family protein CARD11 is essential for lymphocyte activation. Immunity. 2003 Jun;18(6):763-75
• All: 12 reference(s)