Card11^unm
Chemically induced Allele Detail

Summary

• Symbol: Card11^unm
• Name: caspase recruitment domain family, member 11; unmodulated
• MGI ID: MGI:3045963
• Synonyms: Card11^un
• Gene: Card11 Location: Chr5:140858745-140986337 bp, - strand Genetic Position: Chr5, 79.42 cM
• Alliance: Card11^unm page

Mutation origin

• Strain of Origin: C57BL/6JSfdAnu
• Project Collection: APF ENU Mutagenesis

Mutation description

• Allele Type: Chemically induced (ENU) (Hypomorph)
• Mutation: Single point mutation
• Mutation details: Sequencing revealed a T to A transversion that resulted in a leucine to glutamine substitution in a segment predicted to form a coiled coil (CC) domain, and is conserved in the heptad repeats of the predicted alpha-helical coil. Western blot revealed normal levels of protein in mutant B cells. The change from nonpolar leucine to polar glutamine putatively disrupts the CC structure and interferes with protein pairing. (J:84042)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 4 strains available Cell Lines: 0 lines available
• Carrying any Card11 Mutation: 59 strains or lines available

References

• Original: J:84042 Jun JE, et al., Identifying the MAGUK protein Carma-1 as a central regulator of humoral immune responses and atopy by genome-wide mouse mutagenesis. Immunity. 2003 Jun;18(6):751-62
• All: 6 reference(s)