Hoxb4^tm1.1Karl
Targeted Allele Detail

Summary

• Symbol: Hoxb4^tm1.1Karl
• Name: homeobox B4; targeted mutation 1.1, Stefan Karlsson
• MGI ID: MGI:3045971
• Synonyms: Hoxb4^-
• Gene: Hoxb4 Location: Chr11:96209093-96212464 bp, + strand Genetic Position: Chr11, 59.83 cM
• Alliance: Hoxb4^tm1.1Karl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:90976
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Transient cre activity excised floxed exons 1 and 2 and a floxed neo, leaving a single loxp site. RT-PCR demonstrated absence of transcript in mutant mice. (J:90976)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Hoxb4 Mutation: 20 strains or lines available

References

• Original: J:90976 Brun AC, et al., Hoxb4-deficient mice undergo normal hematopoietic development but exhibit a mild proliferation defect in hematopoietic stem cells. Blood. 2004 Jun 1;103(11):4126-33
• All: 2 reference(s)