Lect2^tm1Ymg
Targeted Allele Detail

Summary

• Symbol: Lect2^tm1Ymg
• Name: leukocyte cell-derived chemotaxin 2; targeted mutation 1, Satoshi Yamagoe
• MGI ID: MGI:3045975
• Synonyms: LECT2^-
• Gene: Lect2 Location: Chr13:56690277-56696315 bp, - strand Genetic Position: Chr13, 30.08 cM
• Alliance: Lect2^tm1Ymg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:90961
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A pGK-neo cassette replaced all exons. Southern blot and PCR confirmed recombination and RT-PCR indicted lack of transcript in mutant livers. (J:90961)

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lect2 Mutation: 14 strains or lines available

References

• Original: J:90961 Saito T, et al., Increase in hepatic NKT cells in leukocyte cell-derived chemotaxin 2-deficient mice contributes to severe concanavalin A-induced hepatitis. J Immunol. 2004 Jul 1;173(1):579-85
• All: 6 reference(s)