Slc37a4^tm1Jyc
Targeted Allele Detail

Summary

• Symbol: Slc37a4^tm1Jyc
• Name: solute carrier family 37 (glucose-6-phosphate transporter), member 4; targeted mutation 1, Janice Yang Chou
• MGI ID: MGI:3046091
• Synonyms: G6PT^-/-, Glc-6-PT
• Gene: Slc37a4 Location: Chr9:44308243-44314263 bp, + strand Genetic Position: Chr9, 24.84 cM, cytoband B
• Alliance: Slc37a4^tm1Jyc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:86005
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The coding region of exon 1 as well as a portion of intron 1 were replaced with a neo cassette inserted by homologous recombination. Protein was undetected in homozygous mutant mice by Western blot analysis of liver and kidney microsomal preparations. (J:86005)

Disease models

Expression

In Structures Affected by this Mutation:

9 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Slc37a4 Mutation: 17 strains or lines available

References

• Original: J:86005 Chen LY, et al., Impaired glucose homeostasis, neutrophil trafficking and function in mice lacking the glucose-6-phosphate transporter. Hum Mol Genet. 2003 Oct 1;12(19):2547-58
• All: 8 reference(s)