Gstp1/Gstp2^tm1Wolf
Targeted Allele Detail

Summary

• Symbol: Gstp1/Gstp2^tm1Wolf
• Name: glutathione S-transferase, pi 1; targeted mutation 1, C Roland Wolf
• MGI ID: MGI:3046099
• Synonyms: GstP1/P2^-, GSTpi^-
• Gene: Gstp1 Location: Chr19:4085411-4087912 bp, - strand Genetic Position: Chr19, 3.75 cM
• Alliance: Gstp1/Gstp2^tm1Wolf page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:47638
• Parent Cell Line: E14TG2a (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intergenic deletion
• Mutation details: A single targeting construct was used to replace exons 6 and 7 of the Gstp1 gene and all of the coding sequences for the Gstp2 gene with an en2A-IRES- betageo cassette. Northern and western blot analysis confirmed the absence of Gstp1 transcript and encoded protein. (J:47638)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Gstp1 Mutation: 11 strains or lines available

References

• Original: J:47638 Henderson CJ, et al., Increased skin tumorigenesis in mice lacking pi class glutathione S-transferases. Proc Natl Acad Sci U S A. 1998 Apr 28;95(9):5275-80
• All: 24 reference(s)