Sycn^tm1Rja
Targeted Allele Detail

Summary

• Symbol: Sycn^tm1Rja
• Name: syncollin; targeted mutation 1, Reinhard Jahn
• MGI ID: MGI:3046204
• Gene: Sycn Location: Chr7:28240310-28241634 bp, + strand Genetic Position: Chr7, 16.83 cM, cytoband A3
• Alliance: Sycn^tm1Rja page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:74654
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 1, encoding residues 1-132, was replaced by a neomycin selection cassette. Western blot analysis on zymogen granules derived from adult homozygous mice confirmed that no detectable protein was expressed from this allele. (J:74654)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Sycn Mutation: 8 strains or lines available

References

• Original: J:74654 Antonin W, et al., Loss of the zymogen granule protein syncollin affects pancreatic protein synthesis and transport but not secretion. Mol Cell Biol. 2002 Mar;22(5):1545-54
• All: 2 reference(s)