Isl2^tm2Slp
Targeted Allele Detail

Summary

• Symbol: Isl2^tm2Slp
• Name: insulin related protein 2 (islet 2); targeted mutation 2, Samuel L Pfaff
• MGI ID: MGI:3046260
• Synonyms: Isl2^-
• Gene: Isl2 Location: Chr9:55445956-55453464 bp, + strand Genetic Position: Chr9, 30.13 cM, cytoband C
• Alliance: Isl2^tm2Slp page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:89755
• Parent Cell Line: W9.5/W95 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 4, 5, and 6, which encode the homeodomain and C terminus were replaced with a neomycin resistance cassette. No protein could be detected in homozygous embryos. (J:89755)

Expression

In Mice Carrying this Mutation:	3 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Isl2 Mutation: 28 strains or lines available

References

• Original: J:89755 Thaler JP, et al., A postmitotic role for Isl-class LIM homeodomain proteins in the assignment of visceral spinal motor neuron identity. Neuron. 2004 Feb 5;41(3):337-50
• All: 6 reference(s)