Adgrv1^tm1Pwh
Targeted Allele Detail

Summary

• Symbol: Adgrv1^tm1Pwh
• Name: adhesion G protein-coupled receptor V1; targeted mutation 1, Perrin C White
• MGI ID: MGI:3046273
• Synonyms: Vlgr1^del7TM, VLGR/delTM7
• Gene: Adgrv1 Location: Chr13:81243187-81781273 bp, - strand Genetic Position: Chr13, 42.18 cM
• Alliance: Adgrv1^tm1Pwh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:90899
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 691 bp segment including intron 81 and part of exon 82 was replaced with an HA tag, a 6xHis affinity purification tag, and a translation stop codon via homologous recombination. Western blot analysis confirmed expression of a single mutant protein. (J:90899)

Disease models

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Adgrv1 Mutation: 318 strains or lines available

References

• Original: J:90899 McMillan DR, et al., Loss of the transmembrane and cytoplasmic domains of the very large G-protein-coupled receptor-1 (VLGR1 or Mass1) causes audiogenic seizures in mice. Mol Cell Neurosci. 2004 Jun;26(2):322-9
• All: 7 reference(s)