Mmp9^tm1Arnd
Targeted Allele Detail

Summary

• Symbol: Mmp9^tm1Arnd
• Name: matrix metallopeptidase 9; targeted mutation 1, Bernd Arnold
• MGI ID: MGI:3046278
• Synonyms: MMP-9^-
• Gene: Mmp9 Location: Chr2:164782700-164797770 bp, + strand Genetic Position: Chr2, 85.27 cM, cytoband H1-H2
• Alliance: Mmp9^tm1Arnd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:58833
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 3-7 and part of 8 were deleted and replaced with a neomycin selection cassette. Zymography analysis on leukocyte supernatants confirmed that no fuctional protein was expressed from this allele. (J:58833)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mmp9 Mutation: 50 strains or lines available

References

• Original: J:58833 Dubois B, et al., Resistance of young gelatinase B-deficient mice to experimental autoimmune encephalomyelitis and necrotizing tail lesions. J Clin Invest. 1999 Dec;104(11):1507-15
• All: 26 reference(s)