Serping1^Gt1Aed
Gene trapped Allele Detail

Summary

• Symbol: Serping1^Gt1Aed
• Name: serine (or cysteine) peptidase inhibitor, clade G, member 1; gene trap 1, Alvis E Davis III
• MGI ID: MGI:3046287
• Synonyms: C1INH^-
• Gene: Serping1 Location: Chr2:84595704-84605748 bp, - strand Genetic Position: Chr2, 49.45 cM
• Alliance: Serping1^Gt1Aed page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:76090
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S5/SvEvBrd

Mutation description

• Allele Type: Gene trapped (Null/knockout, Reporter)
• Mutation: Insertion of gene trap vector
• Mutation details: A gene trap vector that contained an IRES-Beta-geo expression/selection cassette inserted into the gene 210 bp upstream of exon 7. Western blot analysis of mouse serum confirmed that no detectable protein was expressed from this allele. (J:76090)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Serping1 Mutation: 31 strains or lines available

References

• Original: J:76090 Han ED, et al., Increased vascular permeability in C1 inhibitor-deficient mice mediated by the bradykinin type 2 receptor. J Clin Invest. 2002 Apr;109(8):1057-63
• All: 3 reference(s)