Cdhr1^tm1Nat
Targeted Allele Detail

Summary

• Symbol: Cdhr1^tm1Nat
• Name: cadherin-related family member 1; targeted mutation 1, Jeremy Nathans
• MGI ID: MGI:3046299
• Synonyms: prCAD^-
• Gene: Cdhr1 Location: Chr14:36799814-36820304 bp, - strand Genetic Position: Chr14, 21.29 cM
• Alliance: Cdhr1^tm1Nat page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:73286
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin selection cassette replaced exons 10-17, which encode the C-terminal two thirds of the protein. Northern blot and immunohistochemical analysis confirmed the absence of encoded transcript and protein, respectively. (J:73286)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Cdhr1 Mutation: 54 strains or lines available

References

• Original: J:73286 Rattner A, et al., A photoreceptor-specific cadherin is essential for the structural integrity of the outer segment and for photoreceptor survival. Neuron. 2001 Dec 6;32(5):775-86
• All: 5 reference(s)