Lrp5^tm1Jfh
Targeted Allele Detail

Summary

• Symbol: Lrp5^tm1Jfh
• Name: low density lipoprotein receptor-related protein 5; targeted mutation 1, J Fred Hess
• MGI ID: MGI:3046356
• Synonyms: Lrp5^-, Lrp^tm1Hes
• Gene: Lrp5 Location: Chr19:3634828-3736564 bp, - strand Genetic Position: Chr19, 3.33 cM, cytoband B
• Alliance: Lrp5^tm1Jfh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:91055
• Parent Cell Line: Lex-1 (ES Cell)
• Strain of Origin: 129S5/SvEvBrd

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The coding portion of exon 1 (197 bp) was replaced with an IRES-beta galactosidase reporter and an MC1-neomycin selection cassette. Absence of transcripts was confirmed by Northern blot analysis. (J:91055)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lrp5 Mutation: 82 strains or lines available

References

• Original: J:91055 Kelly OG, et al., The Wnt co-receptors Lrp5 and Lrp6 are essential for gastrulation in mice. Development. 2004 Jun;131(12):2803-15
• All: 1 reference(s)