Tg(Igk-V21-Bax)1967Bvn
Transgene Detail

Summary

• Symbol: Tg(Igk-V21-Bax)1967Bvn
• Name: transgene insertion 1967, Brian Van Ness
• MGI ID: MGI:3046400
• Synonyms: 3'KE-Bcl-XL, KE/Bcl-XL
• Transgene: Tg(Igk-V21-Bax)1967Bvn Location: unknown
• Alliance: Tg(Igk-V21-Bax)1967Bvn page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Igk-V21-Bax)1967Bvn expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Bax (MGI:99702)

• Mutation details: This transgene consists of 3' enhancer and promoter sequence from the mouse Igk-V21, a flag epitope fused to mouse Bax cDNA, and the 3'UTR from the human growth hormone gene. The highest levels of expression of this transgene are found in the marrow, spleen and lymph nodes. Expression is also restricted to immature/transitional B cells. Three founder lines were generated 1962, 1967 and 2021. (J:89049)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Tg(Igk-V21-Bax)1967Bvn

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:89049 Linden M, et al., Targeted overexpression of Bcl-XL in B-lymphoid cells results in lymphoproliferative disease and plasma cell malignancies. Blood. 2004 Apr 1;103(7):2779-86
• All: 6 reference(s)