Id3^tm1Cmu
Targeted Allele Detail

Summary

• Symbol: Id3^tm1Cmu
• Name: inhibitor of DNA binding 3; targeted mutation 1, Cornelis Murre
• MGI ID: MGI:3046425
• Synonyms: Id3^-
• Gene: Id3 Location: Chr4:135871133-135872703 bp, + strand Genetic Position: Chr4, 68.34 cM
• Alliance: Id3^tm1Cmu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:59969
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The sequences encoding the helix-loop-helix dimerization domain was replaced by a neo cassette via homologous recombination. Northern and western blot analysis confirmed the absence of transcript and protein, respectively, in homozygous mice. (J:59969)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Id3 Mutation: 16 strains or lines available

References

• Original: J:59969 Rivera RR, et al., Thymocyte selection is regulated by the helix-loop-helix inhibitor protein, Id3. Immunity. 2000 Jan;12(1):17-26
• All: 8 reference(s)