Ncoa6^tm1Hhs
Targeted Allele Detail

Summary

• Symbol: Ncoa6^tm1Hhs
• Name: nuclear receptor coactivator 6; targeted mutation 1, Herbert H Samuels
• MGI ID: MGI:3046462
• Synonyms: NRC^-
• Gene: Ncoa6 Location: Chr2:155232585-155315741 bp, - strand Genetic Position: Chr2, 77.26 cM, cytoband H2
• Alliance: Ncoa6^tm1Hhs page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:91083
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The sequences encoding the LxxLL-1 region was replaced with a neo cassette via homologous recombination. (J:91083)

Expression

In Structures Affected by this Mutation:

8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ncoa6 Mutation: 101 strains or lines available

References

• Original: J:91083 Mahajan MA, et al., The nuclear hormone receptor coactivator NRC is a pleiotropic modulator affecting growth, development, apoptosis, reproduction, and wound repair. Mol Cell Biol. 2004 Jun;24(11):4994-5004
• All: 2 reference(s)