Ung^tm1Mend
Targeted Allele Detail

Summary

• Symbol: Ung^tm1Mend
• Name: uracil DNA glycosylase; targeted mutation 1, Matthias Endres
• MGI ID: MGI:3046503
• Synonyms: Ung^-
• Gene: Ung Location: Chr5:114268447-114277384 bp, + strand Genetic Position: Chr5, 55.97 cM, cytoband F
• Alliance: Ung^tm1Mend page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:90910
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 1 - 3 and part of exon 4 were replaced with a neo cassette via homologous recombination. RT-PCR indicated that a transcript consisting of exons 1a and 6 is produced, however activity assays confirmed the absence of activity in homozygous cells. (J:90910)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ung Mutation: 24 strains or lines available

References

• Original: J:90910 Endres M, et al., Increased postischemic brain injury in mice deficient in uracil-DNA glycosylase. J Clin Invest. 2004 Jun;113(12):1711-21
• All: 15 reference(s)