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Pias4tm1Hwu
Targeted Allele Detail
Summary
Symbol: Pias4tm1Hwu
Name: protein inhibitor of activated STAT 4; targeted mutation 1, Hong Wu
MGI ID: MGI:3046514
Synonyms: Piasy-
Gene: Pias4  Location: Chr10:80989795-81003554 bp, - strand  Genetic Position: Chr10, 39.72 cM, cytoband C1
Alliance: Pias4tm1Hwu page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:91085
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe majority of the coding region, exons 3 - 11, was replaced with a neo gene via homologous recombination. RT-PCR and western blot analysis confirmed the absence on RNA and protein expression in homozygous mutants (J:91085)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pias4 Mutation:  25 strains or lines available
References
Original:  J:91085 Wong KA, et al., Protein inhibitor of activated STAT Y (PIASy) and a splice variant lacking exon 6 enhance sumoylation but are not essential for embryogenesis and adult life. Mol Cell Biol. 2004 Jun;24(12):5577-86
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/19/2024
MGI 6.24
The Jackson Laboratory