Meox2^fla
Spontaneous Allele Detail

Summary

• Symbol: Meox2^fla
• Name: mesenchyme homeobox 2; flexed ankles
• MGI ID: MGI:3046541
• Gene: Meox2 Location: Chr12:37158539-37229533 bp, + strand Genetic Position: Chr12, 16.84 cM
• Alliance: Meox2^fla page

Mutation origin

• Strain of Origin: B6C3Fe a/a-Napa^hyh/J

Mutation description

• Allele Type: Spontaneous
• Mutation: Undefined
• Mutation details: This spontaneous mutation arose at The Jackson Laboratory. It was shown to be allelic with Meox2^tm1(cre)Sor by a failed complementation test.
• Inheritance: Recessive

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)
Loading...
hm1	Meox2^fla/Meox2^fla	involves: C3HeB/FeJ * C57BL/6J

Phenotypes:

Affected Systems	hm1
show or hide all annotated terms Sex:
cardiovascular system	√	√
thin myocardium	√	√
limbs/digits/tail	√	√
abnormal gastrocnemius morphology	√	√
muscle	√	√
thin myocardium	√	√
abnormal skeletal muscle morphology	√	√
abnormal gastrocnemius morphology	√	√
reproductive system	√
thin myometrium	√
skeleton	√	√
skeleton phenotype	N	N
joint contracture	√	√

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Meox2 Mutation: 18 strains or lines available

References

• Original: J:123197 Donahue LR, et al., Flexed ankles, a new spontaneous mutation at Meox2. MGI Direct Data Submission. 2007
• All: 1 reference(s)