Bub1b^tm1Jvd
Targeted Allele Detail

Summary

• Symbol: Bub1b^tm1Jvd
• Name: BUB1B, mitotic checkpoint serine/threonine kinase; targeted mutation 1, Jan M A van Deursen
• MGI ID: MGI:3046580
• Synonyms: Bub1b^H, BubR1^H
• Gene: Bub1b Location: Chr2:118428692-118472072 bp, + strand Genetic Position: Chr2, 59.4 cM
• Alliance: Bub1b^tm1Jvd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:91128
• Parent Cell Line: TL1/TL-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Conditional ready, Hypomorph)
• Mutation: Insertion
• Mutation details: A loxP site, neo cassette, and cryptic exon were inserted between exons 5 and 6 and a second loxP site inserted 5' of exon 5 via homologous recombination. Western blot analysis confirmed decreased protein expression from this hypomorphic allele. (J:91128)

Disease models

Expression

In Mice Carrying this Mutation:	33 assay results
In Structures Affected by this Mutation:	9 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Bub1b^tm1Jvd

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Bub1b Mutation: 59 strains or lines available

References

• Original: J:91128 Baker DJ, et al., BubR1 insufficiency causes early onset of aging-associated phenotypes and infertility in mice. Nat Genet. 2004 Jul;36(7):744-9
• All: 23 reference(s)