Bub1b^tm1.1Jvd
Targeted Allele Detail

Summary

• Symbol: Bub1b^tm1.1Jvd
• Name: BUB1B, mitotic checkpoint serine/threonine kinase; targeted mutation 1.1, Jan M A van Deursen
• MGI ID: MGI:3046581
• Synonyms: Bub1b^-
• Gene: Bub1b Location: Chr2:118428692-118472072 bp, + strand Genetic Position: Chr2, 59.4 cM
• Alliance: Bub1b^tm1.1Jvd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:91128
• Parent Cell Line: TL1/TL-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: This allele is derived from Bub1b^tm1Jvd via cre mediated recombination, which excises exon 5 and results in out-frame fusion of exons 4 and 6. (J:91128)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Bub1b Mutation: 59 strains or lines available

References

• Original: J:91128 Baker DJ, et al., BubR1 insufficiency causes early onset of aging-associated phenotypes and infertility in mice. Nat Genet. 2004 Jul;36(7):744-9
• All: 6 reference(s)