Crebbp^tm1Few
Targeted Allele Detail

Summary

• Symbol: Crebbp^tm1Few
• Name: CREB binding protein; targeted mutation 1, Fredric E Wondisford
• MGI ID: MGI:3046630
• Synonyms: CBP^-, CBP-S436A
• Gene: Crebbp Location: Chr16:3899198-4031864 bp, - strand Genetic Position: Chr16, 2.4 cM
• Alliance: Crebbp^tm1Few page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:91133
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Not Specified)
• Mutation: Nucleotide substitutions
• Mutation details: An S436A mutation was inserted via homologous recombination. This interfered with insulin-mediated phosphorylation of this amino acid. (J:91133)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Crebbp Mutation: 100 strains or lines available

References

• Original: J:91133 Zhou XY, et al., Insulin regulation of hepatic gluconeogenesis through phosphorylation of CREB-binding protein. Nat Med. 2004 Jun;10(6):633-7
• All: 8 reference(s)