Ctsw^tm1Ctnp
Targeted Allele Detail

Summary

• Symbol: Ctsw^tm1Ctnp
• Name: cathepsin W; targeted mutation 1, Christine T N Pham
• MGI ID: MGI:3046638
• Synonyms: CtsW^-
• Gene: Ctsw Location: Chr19:5515071-5518535 bp, - strand Genetic Position: Chr19, 4.33 cM, cytoband A
• Alliance: Ctsw^tm1Ctnp page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:91265
• Parent Cell Line: RW-4 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 1 through intron 2 were replaced with a loxP flanked neo cassette via homologous recombination. S1 nuclease protection and western blot analysis confirmed the absence of mRNA and protein in activated lymphocytes from homozygous null mice. (J:91265)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ctsw Mutation: 17 strains or lines available

References

• Original: J:91265 Ondr JK, et al., Characterization of murine cathepsin W and its role in cell-mediated cytotoxicity. J Biol Chem. 2004 Jun 25;279(26):27525-33
• All: 1 reference(s)