Lama1^{GT(PST008)Byg}
Gene trapped Allele Detail

Summary

• Symbol: Lama1^{GT(PST008)Byg}
• Name: laminin, alpha 1; gene trap PST008, BayGenomics
• MGI ID: MGI:3046686
• Synonyms: Lama1^{GT(pGT0TMp)1Wcs}, PST8
• Gene: Lama1 Location: Chr17:68004254-68129642 bp, + strand Genetic Position: Chr17, 38.8 cM
• Alliance: Lama1^{GT(PST008)Byg} page

Mutation origin

• Mutant Cell Line: PST008
• Germline Transmission: Earliest citation of germline transmission: J:91048
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Gene trapped (Null/knockout, Reporter)
• Mutation: Insertion of gene trap vector Vector: pGT0TMp
• Mutation details: This mutation was caused by the insertion of the gene trap vector pGT0TMp into the 3rd intron. The fusion protein includes the first endogenous 121 amino acids, containing the signal sequence and about half of its globular domain VI, followed by the transmembrane domain and Betageo reporter from the vector. (J:67920, J:85792)
• Sequence Tags: Sequence tag details (1 tag)

  Tag ID	GenBank ID	Method	Tag Location (trapped strand)*	Select
  PST008	CC144617 ; (MGI Seq Detail)	5' RACE	Chr17:68023749-68024267 bp (+)
  * GRCm39; (strand of gene trap mutagenesis)

• Genome Context: Genome Browser view of this mutation;

  4 gene trap insertions have trapped this gene; View all gene trap sequence tags in this region

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lama1 Mutation: 186 strains or lines available

References

• Original: J:67920 Leighton PA, et al., Defining brain wiring patterns and mechanisms through gene trapping in mice. Nature. 2001 Mar 8;410(6825):174-9
• All: 4 reference(s)