Chek1^tm1Jmr
Targeted Allele Detail

Summary

• Symbol: Chek1^tm1Jmr
• Name: checkpoint kinase 1; targeted mutation 1, Jeffrey M Rosen
• MGI ID: MGI:3046694
• Synonyms: Chk1 Flox
• Gene: Chek1 Location: Chr9:36619935-36637897 bp, - strand Genetic Position: Chr9, 20.67 cM, cytoband A5.3
• Alliance: Chek1^tm1Jmr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:91266
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: LoxP sites were inserted around a 2.2kb genomic segment containing exon 2 via homologous recombination. (J:91266)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Chek1 Mutation: 41 strains or lines available

References

• Original: J:91266 Lam MH, et al., Chk1 is haploinsufficient for multiple functions critical to tumor suppression. Cancer Cell. 2004 Jul;6(1):45-59
• All: 11 reference(s)