Pip4k2b^{Gt(Betageo)1Lca}
Gene trapped Allele Detail

Summary

• Symbol: Pip4k2b^{Gt(Betageo)1Lca}
• Name: phosphatidylinositol-5-phosphate 4-kinase, type II, beta; gene trap 1, Lewis C Cantley
• MGI ID: MGI:3046749
• Synonyms: PI5P4Kbeta^-
• Gene: Pip4k2b Location: Chr11:97605983-97635530 bp, - strand Genetic Position: Chr11, 61.07 cM
• Alliance: Pip4k2b^{Gt(Betageo)1Lca} page

Mutation origin

• Mutant Cell Line: OST39557
• Germline Transmission: Earliest citation of germline transmission: J:91023
• Parent Cell Line: Lex-1 (ES Cell)
• Strain of Origin: 129S5/SvEvBrd

Mutation description

• Allele Type: Gene trapped (Null/knockout, Reporter)
• Mutation: Insertion of gene trap vector
• Mutation details: A gene trap vector inserted in the first intron 818 bp downstream of the ATG initiation codon. Normal transcripts were undetectable in RNA purified from brain tissue and protein product was undetectable immunologically. (J:91023)
• Sequence Tags: Sequence tag details (1 tag)

  Tag ID	GenBank ID	Method	Tag Location (trapped strand)*	Select
  OST39557	CG498307 ; (MGI Seq Detail)	3' RACE	Chr11:97613188-97623580 bp (-)
  * GRCm39; (strand of gene trap mutagenesis)

• Genome Context: Genome Browser view of this mutation;

  11 gene trap insertions have trapped this gene; View all gene trap sequence tags in this region

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pip4k2b Mutation: 34 strains or lines available

References

• Original: J:91023 Lamia KA, et al., Increased insulin sensitivity and reduced adiposity in phosphatidylinositol 5-phosphate 4-kinase beta-/- mice. Mol Cell Biol. 2004 Jun;24(11):5080-7
• All: 6 reference(s)