Fn1^tm2Bwg
Targeted Allele Detail

Summary

• Symbol: Fn1^tm2Bwg
• Name: fibronectin 1; targeted mutation 2, Brigham and Women's Hospital
• MGI ID: MGI:3046766
• Synonyms: EIIIA^flox
• Gene: Fn1 Location: Chr1:71624679-71692359 bp, - strand Genetic Position: Chr1, 36.05 cM, cytoband C1-C5
• Alliance: Fn1^tm2Bwg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:90917
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: The EIIIA domain encoding exon was floxed following transient cre-mediated excision of an upstream floxed neo. Southern blot confirmed recombination. (J:90917)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fn1 Mutation: 130 strains or lines available

References

• Original: J:90917 Tan MH, et al., Deletion of the alternatively spliced fibronectin EIIIA domain in mice reduces atherosclerosis. Blood. 2004 Jul 1;104(1):11-8
• All: 1 reference(s)