Srf^tm1Zli
Targeted Allele Detail

Summary

• Symbol: Srf^tm1Zli
• Name: serum response factor; targeted mutation 1, Zhenlin Li
• MGI ID: MGI:3046779
• Synonyms: S^f, Srf-flex2neo, Srf^flx
• Gene: Srf Location: Chr17:46859255-46867101 bp, - strand Genetic Position: Chr17, 22.9 cM
• Alliance: Srf^tm1Zli page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:91025
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: LoxP sites were inserted around exon 2 and after a PGK-neo cassette in intron 2 via homologous recombination. Western blot analysis confirmed protein expression from the mutant allele (J:91025)

Disease models

Expression

In Mice Carrying this Mutation:	67 assay results
In Structures Affected by this Mutation:	7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Srf Mutation: 27 strains or lines available

References

• Original: J:91025 Parlakian A, et al., Targeted inactivation of serum response factor in the developing heart results in myocardial defects and embryonic lethality. Mol Cell Biol. 2004 Jun;24(12):5281-9
• All: 25 reference(s)