Pde3a^tm1Vman
Targeted Allele Detail

Summary

• Symbol: Pde3a^tm1Vman
• Name: phosphodiesterase 3A, cGMP inhibited; targeted mutation 1, Vincent Manganiello
• MGI ID: MGI:3046786
• Synonyms: Pde3a^-
• Gene: Pde3a Location: Chr6:141194995-141452588 bp, + strand Genetic Position: Chr6, 71.87 cM, cytoband G1
• Alliance: Pde3a^tm1Vman page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:91348
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neo cassette replaced exon 13, which encodes a portion of the catalytic domain. Western blot indicated mRNA of the mutant allele was transcribed and translated as shorter forms of the protein, putatively lacking the catalytic domain portion encoded by exon 13. (J:91348)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pde3a Mutation: 52 strains or lines available

References

• Original: J:91348 Masciarelli S, et al., Cyclic nucleotide phosphodiesterase 3A-deficient mice as a model of female infertility. J Clin Invest. 2004 Jul;114(2):196-205
• All: 11 reference(s)