Ikbketm1Aki
Targeted Allele Detail
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| Symbol: |
Ikbketm1Aki |
| Name: |
inhibitor of kappaB kinase epsilon; targeted mutation 1, Shizuo Akira |
| MGI ID: |
MGI:3046788 |
| Synonyms: |
Ikk-I- |
| Gene: |
Ikbke Location: Chr1:131182337-131207339 bp, - strand Genetic Position: Chr1, 56.93 cM
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| Alliance: |
Ikbketm1Aki page
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| Germline Transmission: |
Earliest citation of germline transmission:
J:91363
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| Parent Cell Line: |
E14.1 (ES Cell)
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| Strain of Origin: |
129P2/OlaHsd
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| Allele Type: |
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Targeted (Null/knockout) |
| Mutations: |
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Insertion, Intragenic deletion
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Mutation details: A neo cassette replaced exons 7 and 8, which encode part of the kinase domain. Sequencing of mRNA from the mutant allele confirmed lack of exons 7 and 8 and indicated a premature stop codon was created, thereby generating a truncated protein that contained only a part of the kinase domain. A transfection assay showed that mutant protein did not function as the wild-type.
(J:91363)
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View phenotypes and curated references for all genotypes (concatenated display).
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Ikbke Mutation: |
55 strains or lines available
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| Original: |
J:91363 Hemmi H, et al., The Roles of Two IkappaB Kinase-related Kinases in Lipopolysaccharide and Double Stranded RNA Signaling and Viral Infection. J Exp Med. 2004 Jun 21;199(12):1641-50 |
| All: |
14 reference(s) |
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Analysis Tools
