Tbx1^tm2Bld
Targeted Allele Detail

Summary

• Symbol: Tbx1^tm2Bld
• Name: T-box 1; targeted mutation 2, Antonio Baldini
• MGI ID: MGI:3046792
• Synonyms: Tbx1^neo
• Gene: Tbx1 Location: Chr16:18399729-18409412 bp, - strand Genetic Position: Chr16, Syntenic
• Alliance: Tbx1^tm2Bld page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:91013
• Parent Cell Line: AB2.2 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Conditional ready, Hypomorph)
• Mutation: Insertion
• Mutation details: A floxed PGK-neo cassette and a third loxP site were inserted such that cre mediated recombination may excise exon 5 and/or the neo cassette. RT-PCR indicates that this is a hypomorphic allele. (J:91013)

Disease models

Expression

In Mice Carrying this Mutation:	3 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Tbx1 Mutation: 36 strains or lines available

References

• Original: J:91013 Xu H, et al., Tbx1 has a dual role in the morphogenesis of the cardiac outflow tract. Development. 2004 Jul;131(13):3217-27
• All: 4 reference(s)